LILRA6 copy number variation correlates with susceptibility to atopic dermatitis
نویسندگان
چکیده
منابع مشابه
Genetic susceptibility to atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with an increasing prevalence in industrialized countries. AD belongs to the group of allergic disorders that includes food allergy, allergic rhinitis, and asthma. A multifactorial background for AD has been suggested, with genetic as well as environmental factors influencing disease development. Recent breakthroughs in genetic meth...
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Loss-of-function variants within the filaggrin gene (FLG) increase the risk of atopic dermatitis. FLG also demonstrates intragenic copy number variation (CNV), with alleles encoding 10, 11, or 12 filaggrin monomers; hence, CNV may affect the amount of filaggrin expressed in the epidermis. A total of 876 Irish pediatric atopic dermatitis cases were compared with 928 population controls to test t...
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Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human diseaserelevant phenotypes associated with CNV in the mouse can help eluci...
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A large number of analyses of a new form of genetic variation, known as copy number variation (CNV), have been published recently as a new tool for understanding the genetic basis of complex traits such as diabetes, asthma, Crohn's disease, autism and bipolar disorder. Through the use of different types of genome-wide scanning procedures, CNVs have been shown to be associated with several compl...
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2 Atopic dermatitis (AD) is a common chronic inflammatory skin disease. The pathophysiological factors include genetic predisposition to skin barrier defects, dysregulated immunity and hypersensitive allergen response (Novak and Simon, 2011). The high levels of proinflammatory cytokines in AD initiate and maintain the inflammation (Bieber, 2008) and mediates cross-talk between innate and adapti...
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ژورنال
عنوان ژورنال: Immunogenetics
سال: 2016
ISSN: 0093-7711,1432-1211
DOI: 10.1007/s00251-016-0924-z